Loneliness and social isolation may cost people years of healthy life, with an especially striking toll on mental health.
Date:
October 10, 2026 and social isolation can cost people years of healthy life, especially when it comes to mental health. Men experiencing both lost about 5.8 years free from depression and anxiety, while women lost roughly 3.7 years.
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Loneliness and social isolation are widespread in the United States. According to a 2023 report, about half of U.S. adults experience loneliness, while nearly as many are socially isolated. Despite health consequences that can rival other major risk factors, both problems remain relatively overlooked as urgent public health concerns.
Until recently, however, researchers had little idea how many years of good health might actually be lost to loneliness and social isolation.
Loneliness Linked to Fewer Healthy Years
Researchers at Tulane University’s Celia Scott Weatherhead School
Researchers at Tulane University’s Celia Scott Weatherhead School of Public and Tropical Medicine have now attempted to put a number on that toll. Their first-of-its-kind observational study, published in Nature Communications, found that loneliness and social isolation were associated with the loss of nearly six years of life free from mental disorders such as depression and anxiety. The effects on physical health were smaller, but still significant.
“Overall, the study found that social isolation and loneliness can have a significant impact on disease-free life expectancy,” said lead author Lu Qi, HCA Regents Distinguished Chair and professor in Celia Scott Weatherhead School of Public and Tropical Medicine at Tulane. “This includes both physical and mental disease.”
Although loneliness and social isolation are often treated as the same thing in everyday conversation, researchers distinguish between them. Social isolation refers to an objective lack of social connections. Loneliness, by contrast, describes a person’s subjective dissatisfaction with the quality of their relationships, regardless of how many social interactions they actually have.
The findings weren’t surprising to me, Qi said
“The findings weren’t surprising to me,” Qi said. “Previous studies found that social isolation and loneliness are related to mortality, especially premature mortality, and this study provides additional evidence.”
Tracking More Than 277,000 Adults
The researchers analyzed data from 277,489 adults between the ages of 40 and 69. At the beginning of the study, none had seven major chronic conditions: diabetes, heart disease, lung disease, dementia, cancer, depression and anxiety.
Using age 50 as a reference point, the team calculated how loneliness and social isolation were associated with the number of years participants could expect to live without these diseases.
Compared with people who experienced neither loneliness nor
Compared with people who experienced neither loneliness nor social isolation, women experiencing both had 2.4 fewer years free from physical disease. Men experiencing both had 1.7 fewer years.
The difference was even larger for mental health. Women experiencing both loneliness and social isolation lived about 3.7 fewer years without mental disorders, while men lived approximately 5.8 fewer years free from those conditions.
“This comes down to the gender differences between men and women,” Qi said. “Our research found men are more susceptible to being affected by loneliness. We also know that women tend to live longer than men. There are gender advantages with certain diseases.”
Healthy Habits Help With Isolation, but Not Loneliness
The researchers also examined whether lifestyle could alter
The researchers also examined whether lifestyle could alter these associations. Healthier habits, including better diet, regular exercise, sufficient sleep, and not smoking, measurably reduced the loss of disease-free years associated with social isolation.
Loneliness produced a different pattern. A healthier lifestyle did not significantly reduce the additional health risks linked to feeling lonely. That distinction suggests loneliness and social isolation may require different approaches when it comes to protecting health.
The research team plans to study additional population groups in the future and use clinical trials to investigate whether loneliness and social isolation directly cause the health effects observed in the study.
Materials provided by Tulane University. Note: Content may be edited for style and length.
- Xuan Wang, Hao Ma, Yoriko Heianza, Zhaoxia Liang, Oscar H. Franco, Lu Qi. Associations of loneliness, social isolation and healthy lifestyle with life expectancy free of major physical disease and mental disorder. Nature Communications, 2026; 17 (1) DOI: 10.1038/s41467-026-74498-8
Tulane University. “Loneliness may steal nearly 6 years of good health.” ScienceDaily. ScienceDaily, 10 October 2026. <www.sciencedaily.com/releases/2026/10/261006234514.htm>.
Tulane University. (2026, October 10). Loneliness may steal nearly 6 years of good health. ScienceDaily. Retrieved October 11, 2026 from www.sciencedaily.com/releases/2026/10/261006234514.htm
Tulane University. “Loneliness may steal nearly 6 years of good health.” ScienceDaily. www.sciencedaily.com/releases/2026/10/261006234514.htm (accessed October 11, 2026).
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